Bioassay for prostaglandin-like activity of garlic extract using isolated rat fundus strip and rat colon preparation.

نویسندگان

  • A Rashid
  • M Hussain
  • H H Khan
چکیده

Hypotensive effect of garlic extract involving releasing of various prostaglandins is well documented. To further evaluate the prostaglandin-like activity of garlic extract, its effect has been demonstrated using isolated rat fundus strip and rat colon preparation. Garlic extract produced the effects on the isolated tissue similar to those of PGE. The use of this response as a bioassay for prostaglandin is discussed (JPMA 36:138: 1986).

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effect of Aqueous Garlic (Allium sativum L.) Extract on Acetylcholine and Isosorbide-Induced Relaxation of Isolated Aorta in Rat

The hypotensive effect of garlic has been well-documented in human subjects and animals. Since endothelial activity regulates vascular reactivity in physiological and pathophysiological conditions, the aim of the present study was to investigate the effect of garlic on endothelium-dependent and independent relaxation of rat aorta for elucidation of mechanism of the garlic anti-hypertensive effe...

متن کامل

The Protective Effect of Garlic Extract against Acetaminophen-Induced Loss of Mitochondrial Membrane Potential in Freshly Isolated Rat Hepatocytes

Overdose of acetaminophen causes severe hepatic necrosis in humans and experimental animals. Studies on its hepatotoxicity remain a very active area since some of current data are still uncertain. In this study, freshly isolated rat hepatocytes were used to determine the effects of garlic extract and its component, allicin on the acetaminophen-induced cell cytotoxicity and to compare with the e...

متن کامل

Cardioprotective Effect of Garlic Juice on the Isolated Rat Heart in Ischemia- Reperfusion

Background: It has been reported that the chronic oral administration of garlic homogenate protected the rat heart from in vitro ischemic reperfusion injury. However, the biological effects of garlic juice on the heart are expected to be different from oral administration of it. Objective: the present study was designed to investigate the effect of garlic juice on the isolated rat heart in is...

متن کامل

Effect of garlic extract and N-acetylcysteine against fenvalerate-induced oxidative stress in the serum and testis tissue of rat

Background and Objective: Fenvalerate is a component of the pyrethroid pesticide induces oxidative stress. This study was done to determine the effect of garlic extract (GE) and N-acetylcysteine (NAC) against fenvalerate-induced oxidative stress in the serum and testis tissue of rat. Methods: In this experimental study, 42 Wistar rats were randomly allocated into 7 groups including: control gr...

متن کامل

Effect of Hydroalcoholic Extract of Pycnocycla spinosa on Rat Isolated Bladder Contraction

Hydroalcoholic extract of Pycnocycla spinosa is a relaxant of rat ileum and inhibits diarrhea in mice. As P. spinosa extract has spasmolytic activity on ileum, it could also affect other smooth muscles like bladder. Therefore, the aim of this study was to determine the effect of P. spinosa extract on rat bladder contraction. In an in vitro study, the effects of P. spinosa extract, nifedipine ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • JPMA. The Journal of the Pakistan Medical Association

دوره 36 6  شماره 

صفحات  -

تاریخ انتشار 1986